Homeostatic control of B lymphocyte subsets

B lymphocyte subsets in patients with rhinoscleroma.

OBJECTIVE To identify the presence of B lymphocytes in the rhinoscleroma granulomas as a possible precursor of plasma cells, whose presence has always been described but whose role is still unclear. STUDY DESIGN Case series with chart review. SETTING Sapienza University of Rome. METHODS The study was carried out on 6 patients (3 women, 3 men). The following parameters were examined for ea...

Lymphocyte Subsets Regulation and Function of Cyclin D2 in B

CD8+ T Lymphocyte Subsets in Bladder Tumor Draining Lymph Nodes

Background: Cytotoxic CD8+ T cells, as essential parts of the adaptive immune system, play pivotal roles in anti-tumor immune responses. It is well documented that cytokine expression profiles and activation status of these cells during anti-tumor immune responses affect the outcome of host-tumor interaction. Objective: To investigate the percentages of CD8+ lymphocytes and their subsets in...

Discovering lymphocyte subsets

At a scientific meeting in 1968, Jacques Miller was accused of complicating immunology. He and others suggested that there was not one but two kinds of lymphocytes--one from the thymus and one from the bone marrow. In a pair of groundbreaking articles published in the Journal of Experimental Medicine in 1968, Miller and his student Graham Mitchell proved that two subsets of lymphocytes did exis...

Lymphocyte subsets and activation.

The biology of lymphocytes is regulated by a large and seemi& growing number of soluble and cell-associated species. A current list includes: interleukins IL l-7, interferons, antigen and perhaps CD4 and cytokines derived from non-lymphoid tissues such as neuropepride, steroid and admnergic hormones. The quality and quantity of regulators present in the B cell milieu during an immunologic insul...